disease

Parkinson'S Disease

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about Parkinson'S Disease: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

7018Connections

0Hypotheses

8Analyses

24Outgoing

50Incoming

No summary available yet. View on Wiki →

Disease Info

Associated Genes	SNCA, SLC6A3, TUBB, NDUFA9, CLU, VPS35, LRRK2, GLUD1
Therapeutic Agents	Kaempferol, Methylene Blue, Glp-1 Receptor Agonists, Glp1R Agonists, Disease-Modifying Treatments, Vinpocetine
KG Connections	257 knowledge graph edges
Databases	OMIM Orphanet ClinicalTrials PubMed

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    Parkinson_S_Disease["Parkinson'S Disease"] -->|"causes"| Neurodegeneration["Neurodegeneration"]
    style Neurodegeneration fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#fff
    Parkinson_S_Disease["Parkinson'S Disease"] -->|"associated"| Protein_Aggregation["Protein Aggregation"]
    style Protein_Aggregation fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    Parkinson_S_Disease["Parkinson'S Disease"] -->|"associated"| Neuroinflammation["Neuroinflammation"]
    style Neuroinflammation fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#fff
    Parkinson_S_Disease["Parkinson'S Disease"] -->|"therapeutic target"| Non_Coding_Rna["Non-Coding Rna"]
    style Non_Coding_Rna fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    Parkinson_S_Disease["Parkinson'S Disease"] -->|"associated"| Executive_Dysfunction["Executive Dysfunction"]
    style Executive_Dysfunction fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#fff
    Parkinson_S_Disease["Parkinson'S Disease"] -->|"associated"| Dopaminergic_Neurons["Dopaminergic Neurons"]
    style Dopaminergic_Neurons fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    Parkinson_S_Disease["Parkinson'S Disease"] -->|"associated"| Substantia_Nigra["Substantia Nigra"]
    style Substantia_Nigra fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    SNCA["SNCA"] -->|"associated"| Parkinson_S_Disease["Parkinson'S Disease"]
    style SNCA fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    SLC6A3["SLC6A3"] -->|"associated"| Parkinson_S_Disease["Parkinson'S Disease"]
    style SLC6A3 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    TUBB["TUBB"] -->|"associated"| Parkinson_S_Disease["Parkinson'S Disease"]
    style TUBB fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    NDUFA9["NDUFA9"] -->|"associated"| Parkinson_S_Disease["Parkinson'S Disease"]
    style NDUFA9 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    Gut_Microbiota["Gut Microbiota"] -->|"associated"| Parkinson_S_Disease["Parkinson'S Disease"]
    style Gut_Microbiota fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#fff
    style Parkinson_S_Disease fill:#ef5350,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0,font-weight:bold

Outgoing (2873)

Target	Relation	Type	Str
Neurodegeneration	causes	process	0.95
Neurodegeneration	associated_with	process	0.95
Neuroinflammation	associated_with	process	0.92
Non-Coding Rna	therapeutic_target	compound	0.92
Executive Dysfunction	associated_with	phenotype	0.90
Dopaminergic Neurons	associated_with	cell_type	0.90
Substantia Nigra	associated_with	cell_type	0.90
Motor Decline	causes	phenotype	0.90
Cognitive Decline	causes	phenotype	0.90
Inflammation	associated_with	process	0.90
Viral Vector Gene Therapy	treats	drug	0.90
Nigrostriatal Degeneration	causes	process	0.90
Dopaminergic Neurons	causes	cell_type	0.90
Substantia Nigra Pars Compacta	causes	cell_type	0.90
Movement Abnormalities	causes	phenotype	0.90
Cognitive Dysfunction	causes	phenotype	0.90
Mood Disorders	causes	phenotype	0.90
Alzheimer'S Disease	associated_with	disease	0.88
MICROGLIA	activates	cell_type	0.85
Brain Structure	causes	phenotype	0.85
Neurons	targets	cell_type	0.85
Atypical Parkinsonism	associated_with	disease	0.80
Type 2 Diabetes Mellitus	associated_with	disease	0.75
Gut-Brain Axis	associated_with	pathway	0.70

Incoming (4145)

Source	Relation	Type	Str
SNCA	associated_with	gene	0.95
SLC6A3	associated_with	gene	0.95
TUBB	associated_with	gene	0.95
NDUFA9	associated_with	gene	0.95
SNCA	causes	protein	0.95
Gut Microbiota	associated_with	process	0.95
SNCA	biomarker_for	protein	0.95
Oxidative Stress	contributes_to	process	0.95
GBA	risk_factor_for	gene	0.95
Dopaminergic Neuron Loss	causes	process	0.95
NLRP3	involved_in	protein	0.95
Neuroinflammation	associated_with	process	0.95
Stem Cell Therapies	treats	process	0.95
PRKN	associated_with	gene	0.95
Mitochondrial Dysfunction	contributes_to	process	0.95
RIP3	protects_against	gene	0.95
Acupuncture	treats	process	0.95
Dopaminergic Neurons	risk_factor_for	cell_type	0.95
SNCA	involved_in	protein	0.95
Chronic Inflammation	associated_with	process	0.95
Parthanatos	involved_in	pathway	0.95
Brain Aging	risk_factor_for	process	0.95
Atremorine	treats	drug	0.95
Dopaminergic Neurons	involved_in	cell_type	0.95
Ageing	risk_factor_for	process	0.95
Α-Synuclein	associated_with	protein	0.95
RGS6	protects_against	gene	0.95
Levodopa	treats	drug	0.95
Gut Microbiota	regulates	process	0.95
Miro1	associated_with	protein	0.95
RHOT1	associated_with	gene	0.95
NOTCH2NLC	risk_factor_for	gene	0.95
Dopamine Biosynthesis	involved_in	pathway	0.95
Neuroinflammation	involved_in	process	0.95
Dopaminergic Synapse Function	involved_in	pathway	0.95
AUTOPHAGY	involved_in	process	0.95
Exercise	protects_against	process	0.95
METTL3	risk_factor_for	gene	0.95
LRRK2	therapeutic_target	gene	0.95
SNCA	implicated_in	protein	0.95
OTUD6A	promotes	gene	0.95
Α-Synuclein Aggregation	contributes_to	process	0.95
LRRK2	causes	gene	0.95
Glucose Metabolic Reprogramming	associated_with	process	0.92
SIRT1	treats	gene	0.92
PKM2	associated_with	gene	0.92
Neurotransmitter Transport	involved_in	pathway	0.92
Oligodendrocyte	involved_in	cell_type	0.90
Microbiota-Gut-Brain Axis	involved_in	pathway	0.90
Gut-Brain Axis	involved_in	pathway	0.90

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (8)

Scientific analyses that reference this entity

How do oligodendrocytes initiate neuroinflammation in PD when microglia are trad

neuroinflammation | 2026-04-13 | 2 hypotheses Top: 0.632

What molecular mechanisms underlie Atremorine's dramatic dopamine enhancement in

neurodegeneration | 2026-04-13 | 2 hypotheses Top: 0.467

GBA-Synuclein Loop Therapeutics for PD

neurodegeneration | 2026-04-01 | 0 hypotheses

GBA-Synuclein Loop: Therapeutic Strategies for Parkinson's Disease

neurodegeneration | 2026-04-01 | 0 hypotheses

What are the mechanisms by which gut microbiome dysbiosis influences Parkinson's

neurodegeneration | 2026-04-01 | 0 hypotheses

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Parkinson'S Disease

Understanding Entity Pages

Wiki Pages (20)

cbs-psp-daily-action-plan

Personalized Treatment Plan — Atypical Parkinsonism (CBS/PSP)

Clinical Management Guide for CBS/PSP

Progressive Supranuclear Palsy (PSP)

Corticobasal Syndrome (CBS)

Novel Therapy Index